Vincent Dole

摘要

By the time he began working on the narcotic addiction research that would make him world renowned, Vincent Dole had already established himself in the metabolism research community investigating hypertension and lipid chemistry. Dole started at the Rockefeller Institute in 1941, working with D D van Slyke. Jules Hirsch joined the Rockefeller in 1954 and he recalled in the Journal ofClinical Investigation in 2004 how at that time Dole was using "a syringe-like accurate delivery system known as a Rehberg burette to determine how much 'free' fatty acid there might be in extracts of plasma lipids", which scientists were beginning to implicate in arteriosclerosis. "Vince tested the method on his own blood, before and after eating very fatty, and I would imagine delicious, breakfasts", Hirsch continued. "He found that non-esterified fatty acid levels declined after a meal", and reported the results in a 1956 Journal of Clinical Investigation paper.