Reduced neuronal responsiveness to visual sexual stimuli in a pedophile treated with a long-acting LH-RH agonist.

摘要

The introduction of long-acting luteinizing hormone-releasing hormone (LH-RH) agonists in the early 1990s opened up a new era in the management of paraphilic disorders. Despite the fact that they are not yet officially approved and may have significant side effects [1], there is first evidence for their efficiency especially in suppressing pedophilic urges and arousability [2], In the past 2 years, a growing body of literature has appeared on functional brain correlates of sexual arousal in clinical populations [3] and particularly with regard to pedophilia, where also morphological deficiencies could be verified [4-8]. Here, we report first evidence of an altered neuronal response pattern in a pedophile treated with an LH-RH agonist.