In this very well-written manuscript, the authors address the crucial question of the prevalence of crucial fibrinolysis after injury and offer a suggestion for a treatment threshold where antinbrinolytics should be administered. In their work, they show that in a relatively small and treatment selected cohort, 26% of patients have any detectable fibrinolysis, with 11 patients (15%) having fibrinolysis greater than an LY30 >3%. They then go on to show a correlation of fibrinolysis with hypotention (but interestingly not injury severity). Lastly, to test the correlation between transfusion requirements and fibrinolysis, the authors separated the injured patients into cohorts defined by LY30 and report the strongest association with need for transfusion beginning at the inflection point of LY30 >3%.
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