Quercetin-3-O-glucronide inhibits noradrenaline binding to alpha_2-adrenergic receptor, thus suppressing DNA damage induced by treatment with 4-hydroxyestradiol and noradrenaline in MCF-10A cells

摘要

Risk factors for breast cancer include estrogens such as 17beta-estradiol (E_2) and high stress levels. 4-Hydroxyestradiol (4-OHE_2), a metabolite of E_2 formed preferentially by cytochrome P4501 B1, is oxidized to E_2-3,4-quinone, which reacts with DNA to form depurinating adducts that exert genotoxicity and car-cinogenicity. Endogenous catecholamines such as adrenaline (A) and noradrenaline (NA) are released from the adrenal gland and sympathetic nervous system during exposure to stress.