Efficient Preparation of Aminoxyacyl Amides, Aminoxy Hybrid Peptides,and a-Aminoxy Peptides

摘要

N-(Pg-a-aminoxy acids) la–g are converted to N-(Pg-a-aminoxyacyl)benzotriazoles 2a–g, whichreact under mild conditions with amines, a-amino acids/a-dipeptides, and a-aminoxy acids to giveaminoxyacyl amides 3a–g, (3e + 3e'), and (3g + 3g'), aminoxy hybrid peptides 4a–h, (4a + 4a'), 6a–d,9a–e, (9a + 9a'), and (96 + 96'), and a-aminoxy peptides 10a,b in good yields without racemization.