Cerium(IV) Ammonium Nitrate Is an Excellent,General Catalyst for the Friedlander andFriedlander-Borsche Quinoline Syntheses:Very Efficient Access to the Antitumor AlkaloidLuotonin A

摘要

The use of cerium(IV) ammonium nitrate as a catalyst ofthe Friedlander reaction allows the synthesis of polysub-stituted quinoline derivatives in excellent yields, avoidingthe traditional harshly basic or acidic conditions. Unlikemost other previously known reagents, CAN allowsdouble condensations and is also an excellent catalystfor the Borsche variation of the Friedlander reaction,which has been applied to the very efficient synthesis ofthe antitumor alkaloid luotonin A.