Modified palladium-catalyzed sonogashira cross-coupling reactions under copper-, amine-, and solvent-free conditions

摘要

PdCl2(PPh3)(2) combined with TBAF under solvent-free conditions provided general and fast Sonogashira cross-coupling reactions of aryl halides with terminal alkynes. In particular, this protocol could be applied to the reactions of deactivated aryl chlorides. In the presence of 3 mol % of PdCl2(PPh3)(2) and 3 equiv of TBAF, a number of ArX species (X = 1, Br, Cl) were coupled with alkynes to afford the corresponding products in moderate to excellent yields under copper-, amine-, and solvent-free conditions.