Conjugate Addition of Amines to an alpha,beta-Unsaturated Imine Derived from alpha-Aminophosphonate. Synthesis of gamma-Amino-alpha-dehydroaminophosphonates

摘要

Aza-Michael reaction of ammonia, aliphatic, aromatic and optically active amines to an (alpha,beta-unsaturated imine derived from alpha-aminophosphonate affords (alpha-dehydroaminophosphonates with a gamma-stereogenic center bearing an amino group. Resulting gamma-amino alpha-dehydroaminophosphonates can be used for the preparation of phosphorylated pyrimidine derivatives.