Synthesis of Passerini-Ugi Hybrids by a Four-Component Reaction Using the Glycolaldehyde Dimer

摘要

Over the past decades, multicomponent reactions (MCRs) have demonstrated their ability and efficiency in the generation of chemical diversity.1 For this reason, MCRs are featured in many diversity-oriented projects, whose biological relevance has been validated by the discovery of novel biological probes and drug leads.2 The Ugi four-component reaction3 and the Passerini three-component reaction4 are the two most important and used isocyanide-mediated MCRs.5