β,β-Disubstituted C- and N-Vinylindoles fromOne-Step Condensations of Aldehydes and IndoleDerivatives

摘要

Direct preparation of β,β-disubstituted C- and N-vinyl-indoles from condensation of aldehydes on indole deriva-tives is presented. Heating 1-methyl- and 1-benzylindole3a,b with alkyl and aryl a-branched aldehydes and TFA inacetonitrile using microwave irradiation furnished 3-vinyl-indoles la-e in 18-76% yields. Under similar conditions,3-substituted indoles 4a-c provided N-vinylindoles 2a-hin 16-98% yields.