Progress toward the Total Synthesis of Lucentamycin A: Total Synthesis and Biological Evaluation of 8-epi-Lucentamycin A

摘要

Synthetic efforts toward the cytotoxic peptides lucenta-mycins A-D are described that resulted in the totalsynthesis and biological evaluation of 8-epi-lucentamycinA in 15 steps with 2.2% overall yield. The key epi-nonproteogenic 3-methyl-4-ethylideneproline was syn-thesized via a titanium-mediated cycloisomerization re-action.