Facile Entry into Triazole Fused Heterocycles viaSuffamidate Derived Azido-alkynes

摘要

Direct synthesis of condensed triazoles from diversesulfamidates by ring opening of sulfamidates with sodiumazide followed by one-pot propargylation and cycloadd-ition furnished title compounds. The methodology ingeneral has been demonstrated on diverse sulfamidatesderived from amino acids, amino acid derivatives, andcarbohydrates to obtain diverse triazole fused scaffolds.In one example, a condensed triazole containing aminoacid has been synthesized by ring opening of a sulfarni-date derivative with propargyl amine.