Synthesis of Substituted Pyrrolin-4-ones from AminoAcids in Mild Conditions via a Gold-CatalyzedApproach

摘要

The gold-catalyzed cyclization of various a-amino-ynonederivatives gave the corresponding pyrrolin-4-ones inhigh yields. Moreover, the use of gold(III) oxide ascatalyst allows a moderate to total stereocontrol duringthe cyclization. These pyrrolin-4-ones are highly usefulintermediates for the synthesis of functionalized pyrroli-dines and other natural products.