In situ generation of 3,3,3-trifluoropropanal and its use for carbon-carbon bond-forming reactions

摘要

The DIBAL reduction of 2-phenylethyl 3,3,3-trifluoro-2-methylpropionate 2 at -78 degrees C afforded the aluminum acetal 3, and this intermediate, on Worming Lip to 0 T, Was found to slowly decompose into the corresponding aldehyde 4, which smoothly reacted with appropriate nucleophiles in a one-pot manner in good to excellent yields with Lip to 93% diastereoselectivity.