Catalytic Enantioselective Approach to the Stereodivergent Synthesis of (+)-Lasubines I and II

摘要

A concise and efficient approach to the stereodivergent synthesis of (+)-lasubines I and II is described. The key common intermediate is a chiral N-sulfonyl 2,3-dihydropy-ridone obtained by a novel Cu-catalyzed asymmetric formal aza-Diels—Alder reaction between N-tosyl aldimines and Danishefsky's diene.