A Practical Synthesis of Tris(pyrazolyl)methylaryls

摘要

The preparation of three tris(pyrazolyl)toluidines from trif-luoromethylaniline reagents is described that likely takes advantage of(quinoidal)resonance-stabilized activation of the C-F bonds.Subsequent transformations lead to two additional(for a total of five new)tris(pyrazolyl)methylaryls.This simple reaction is remarkable because only one other tris(pyrazolyl)methylaryl has been reported previously,because it is usually very difficult to activate fluoroalkane C-F bonds,and because of the potential scope of the reaction.