Gold- and iodine-mediated internal oxygen transfer of nitrone- and sulfoxide-functionalized alkynes

摘要

Intramolecular oxygen transfer of nitrone- and sulfoxide-alkynes was achieved using a catalytic amount of Au(I) and a stoichiometric amount of iodine. The Au(I)-catalyzed cyclization of a nitrone-terminal alkyne afforded a cyclic iminoester, while cyclization of analogous nitrone-internal alkynes yielded aldehyde-enones. The I_2-mediated cyclization of nitrone-alkynes afforded iodinated γ-lactams and the I_2- mediated internal redox of the closely related sulfoxide-alkynes gave diketones functionalized with a thoiether.