Lactam Synthesis via the Intramolecular Hydroamidation of Alkynes Catalyzed by Palladium Complexes

摘要

The palladium complexes catalyzed intramolecular hydro-amidation reaction of amidoalkynes gives the corresponding lactams in good to high yields.For example,in the presence of 10 mol % of Pd(PPh_3)_4 and 20 mol % of PhCOOH,the reaction of the amidoalkyne 3a in 1,4-dioxane at 100 deg C proceeded smoothly to give the corresponding lactam 4a in 92% yield.