首页> 外文期刊>The Journal of Organic Chemistry >Asymmetric Rh(I)-catalyzed addition of MIDA boronates to N-Tert -butanesulfinyl aldimines: Development and comparison to trifluoroborates
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Asymmetric Rh(I)-catalyzed addition of MIDA boronates to N-Tert -butanesulfinyl aldimines: Development and comparison to trifluoroborates

机译:MIDA硼酸酯不对称Rh(I)催化加成到N-叔-丁亚磺酰基醛亚胺中:与三氟硼酸酯的开发和比较

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摘要

The Rh(I)-catalyzed addition of alkenyl and aryl MIDA boronates to N-tert-butanesulfinyl aromatic and aliphatic imines proceeds in good yields (up to 99%) and with very high selectivity (98:2 to >99:1). In comparison to trifluoroborates, higher yields and selectivities are observed for the addition to N-tert-butanesulfinyl aromatic imines. This new method expands upon the versatility of the Rh(I)-catalyzed addition of boron reagents to imines, thereby further enabling the synthesis of chiral α-branched amines.
机译:Rh(I)催化的烯基和芳基MIDA硼酸酯加成到N-叔丁亚磺酰基芳族和脂族亚胺上的收率很高(高达99%),并且选择性很高(98:2至> 99:1)。与三氟硼酸盐相比,对于N-叔丁烷亚磺酰基芳族亚胺的添加,观察到更高的产率和选择性。这种新方法扩展了Rh(I)催化向亚胺中添加硼试剂的通用性,从而进一步实现了手性α-支化胺的合成。

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