Approaches to formation of the eleutheside nucleus based on (+)-delta-Cadinol

摘要

Schemes for synthesizing eleuthesides 1 [1], new cytotoxic marine metabolites, are based on the use of the monoterpenes (+)-carvone [2,3]or (-)-alpha-phellandrene [4.5]. We think that the sesquiterpenoid (+)-delta-cadinol (2) structure can act as an alternate platform for constructing the eleutheside nucleus through an intermediate like 3 [2,3].