STAGEWISE CONTROL OF THE PRODUCTION OF ALLAPININ FROM THE HERB Aconitum leucostomum

摘要

The industrial source for the preparation of the antiarrhythmic drug allapinin [1] is the epigeal part of aconite nionkshood Aconitum leucostomum Woroch (fam. Ranunculaceae). The production of allapinin consists of several stages. To create the optimum conditions for conducting the technical process and for the output of allapinin the materials entering the process and the final product must be strictly controlled. The control of production must be carried out in short times, and the use of an express method of analysis in place of the lengthy ajtid laborious methods used previously [2, 3] is an urgent matter. We have previously developed an accelerated method for the quantitative determination of allapinin in the herb aconite monkshood [4].