Efficacy and Safety of Argatroban and Bivalirudine in Patients with Suspected Heparin-Induced Thrombocytopenia

摘要

Background: Argatroban is the only commercially available Food and Drug Administration (FDA)-approved anticoagulant for managing heparin-induced thrombocytopenia (HIT). However, bivalirudin may be an attractive alternative. Objective: To assess the efficacy and safety of argatroban and bivalirudin in patients with suspected HIT. Methods: This single-center, retrospective analysis included patients who received argatroban or bivalirudin for at least 24 hours between January 1, 2000, and June 30, 2012. The primary end point assessed anticoagulation goals, specifically time to therapeutic activated partial thromboplastin time (aPTT) goal and percentage of aPTT values within therapeutic range. Secondary end points included new thromboembolic events, bleeding, and mortality. Results: Of the 68 patients who met the inclusion criteria, 48 received argatroban and 20 received bivalirudin. Baseline characteristics were similar between the 2 groups except for age, percentage of patients with liver dysfunction, aPTT immediately prior to drug initiation, and the serotonin release assay results. The mean +/- SD times to reach therapeutic aPTT goal for argatroban and bivalirudin were 14 +/- 15 and 7 +/- 8 hours, respectively (P = 0.024). The mean +/- SD percentage of aPTT values within therapeutic aPTT goal was 69% +/- 23% for argatroban and 84% +/- 18% for bivalirudin (P = 0.005). Rates of thromboembolic events were similar between the 2 groups, as were the rates of bleeding and all-cause mortality. Conclusions: Bivalirudin appears to reach therapeutic aPTT goal faster with more aPTT values within therapeutic aPTT goal while achieving similar clinical outcomes. Although not approved by the FDA for managing HIT, bivalirudin may be an attractive alternative anticoagulant.