Direct resolution of the enantiomers of new diphosphine and diphosphine oxide ligands by high-performance liquid chromatography

摘要

Resolution of the enantiomers of new racemic diphosphines, which are very useful ligands for stereoselective catalysts, and of the corresponding phosphine oxides has been investigated by high-performance liquid chromatography (HPLC) on four different chiral stationary phases (CSP) - Chiralpak AD, Whelk-01, and Supelcosil naphthylurea and phenylurea columns. The mobile phases were optimized to achieve separation of the enantiomers. alpha and R-S values ranged from 1.05 to 5.17 and from 0.37 to 6.57, respectively, for the Chiralpak AD and (PR)Whelk-01 columns. For the Supelcosil LC-(R)-phenylurea and Supelcosil LC-(S)-naphthylurea columns alpha values ranged from 1.05 to 1.62 and R-S from 0.35 to 3.61. [References: 21]