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首页> 外文期刊>The Journal of Nuclear Medicine >Myocardial 18F-FDG Uptake After Exercise-Induced Myocardial Ischemia in Patients with Coronary Artery Disease.
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Myocardial 18F-FDG Uptake After Exercise-Induced Myocardial Ischemia in Patients with Coronary Artery Disease.

机译：运动诱发的冠状动脉疾病患者的心肌缺血后的心肌18F-FDG摄取。

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We have recently demonstrated the potential of (18)F-FDG as an imaging marker of myocardial ischemia if injected at peak exercise. However, how long increased (18)F-FDG uptake can be observed after an episode of exercise-induced myocardial ischemia is not known. We performed the current study to determine whether increased regional myocardial (18)F-FDG uptake at exercise in patients with coronary artery disease (CAD) persists on rest imaging (24 h later), after an episode of exercise-induced myocardial ischemia. METHODS: Twenty-four patients with suspected CAD underwent exercise (99m)Tc-sestamibi and (18)F-FDG imaging. Repeated (18)F-FDG imaging was performed 24 h after exercise imaging, after an injection of a second dose of (18)F-FDG at rest in 20 patients. Perfusion imaging with (99m)Tc-sestamibi was simultaneously performed with (18)F-FDG imaging. All patients underwent coronary angiography. RESULTS: Eighteen patients had greater than or equal to 70% luminal narrowing of 1 or more coronary vessels.Fifteen patients (83%) showed increased regional (18)F-FDG uptake on exercise imaging, but only 11 patients (61%) had perfusion abnormalities. Of these 15 patients with increased regional (18)F-FDG uptake on exercise imaging, 8 (53%) had no discernible (18)F-FDG uptake, 5 (33%) had decreased (18)F-FDG uptake, and only 2 (13%) had persistent (18)F-FDG uptake on rest (18)F-FDG images. The summed (18)F-FDG uptake score significantly decreased, from 14.4 +/- 10.3 at exercise to 6.7 +/- 9.2 at rest (P = 0.01). Patients with persistent (18)F-FDG uptake at rest had more (18)F-FDG uptake and lower peak rate-pressure product at exercise, compared with patients with no residual (18)F-FDG uptake at rest. CONCLUSION: Exercise-induced regional myocardial (18)F-FDG uptake is highly specific and sensitive for exercise-induced myocardial ischemia. Regional myocardial (18)F-FDG uptake may persist 24 h after an episode of exercise-induced myocardial ischemia in some patients.
机译：我们最近已经证明，如果在高峰运动时注射，（18）F-FDG可能作为心肌缺血的成像标志物。但是，尚不清楚运动诱发的心肌缺血发作后多长时间可以观察到（18）F-FDG吸收。我们进行了本项研究，以确定运动诱发的心肌缺血发作后，在静止成像（24小时后）后，冠心病（CAD）患者运动时局部心肌（18）F-FDG摄取是否持续增加。方法：二十四例疑似CAD患者接受了（99m）Tc-司他米比和（18）F-FDG成像检查。在运动成像后24小时，在20例患者静注第二剂量的（18）F-FDG后，重复进行了（18）F-FDG成像。 （99m）Tc-司他米比的灌注成像与（18）F-FDG成像同时进行。所有患者均接受冠状动脉造影。结果：18例患者的1个或1个以上冠状动脉腔狭窄缩小大于或等于70％; 15例（83％）在运动成像中显示区域（18）F-FDG摄取增加，但只有11例（61％）灌注异常。在这15例运动成像中区域（18）F-FDG摄取增加的患者中，有8名（53％）没有明显的（18）F-FDG摄取，5名（33％）减少了（18）F-FDG摄取，并且只有2个（13％）的静止（18）F-FDG图像持续摄取（18）F-FDG图像。总的（18）F-FDG摄取分数从运动时的14.4 +/- 10.3显着降低到休息时的6.7 +/- 9.2（P = 0.01）。与没有静息（18）F-FDG摄取的患者相比，静息持续摄取（18）F-FDG的患者在运动时具有更多（18）F-FDG摄取和较低的峰值速率压力乘积。结论：运动诱发的局部心肌（18）F-FDG摄取对运动诱发的心肌缺血具有高度特异性和敏感性。在某些患者中，运动诱发的心肌缺血发作后24小时，局部心肌（18）F-FDG的摄取可能会持续。

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