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首页> 外文期刊>The Journal of Nuclear Medicine >Efficacy of carvedilol treatment on cardiac function and cardiac sympathetic nerve activity in patients with dilated cardiomyopathy: comparison with metoprolol therapy.
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Efficacy of carvedilol treatment on cardiac function and cardiac sympathetic nerve activity in patients with dilated cardiomyopathy: comparison with metoprolol therapy.

机译：卡维地洛治疗对扩张型心肌病患者心功能和心脏交感神经活动的疗效：与美托洛尔治疗的比较。

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Carvedilol and metoprolol have been reported to be effective in the treatment of patients with chronic heart failure. However, to our knowledge, there have been no studies comparing the effects of the 2 drugs on cardiac function, including cardiac sympathetic nerve activity. METHODS: We compared 15 patients with dilated cardiomyopathy (DCM) who were receiving carvedilol (group A) with 15 patients with DCM who were receiving metoprolol (group B). Before and after 1 y of treatment, cardiac (123)I-metaiodobenzylguanidine ((123)I-MIBG) uptake was assessed using the total defect score (TDS) and the heart-to-mediastinum (H/M) activity ratio from the delayed images. The New York Heart Association (NYHA) class and echocardiographic left ventricular ejection fraction (LVEF) also were assessed. RESULTS: In both groups, the TDS decreased (in group A, from 25 +/- 14 to 16 +/- 14, P < 0.01; in group B, from 27 +/- 9 to 19 +/- 10, P < 0.01), the H/M increased (in group A, from 1.67 +/- 0.31 to 2.01 +/- 0.36, P < 0.01; in group B, from 1.68 +/- 0.21 to 1.93 +/- 0.32, P < 0.01), the LVEF increased (in group A, from 31% +/- 10% to 48% +/- 10%, P < 0.01; in group B, from 28% +/- 9% to 47% +/- 15%, P < 0.01), and the NYHA functional class improved (in group A, from 2.9 +/- 0.3 to 1.7 +/- 0.5, P < 0.01; in group B, from 2.8 +/- 0.6 to 1.7 +/- 0.6, P < 0.01). The change in LVEF was mildly correlated with the change in the TDS in group A (r = 0.41) as well as in group B (r = 0.53). In the patients with a favorable response in the TDS or H/M, the NYHA class improved more than in the patients without a favorable response (P < 0.05). CONCLUSION: Carvedilol treatment can improve cardiac function, symptoms, and cardiac sympathetic nerve activity in patients with DCM to a similar extent as metoprolol treatment. The improvement of cardiac function and symptoms is related to the improvement of cardiac sympathetic nerve activity.
机译：据报道，卡维地洛和美托洛尔对慢性心力衰竭患者有效。然而，据我们所知，尚无研究比较这两种药物对心脏功能（包括心脏交感神经活动）的影响。方法：我们比较了接受卡维地洛的15例扩张型心肌病（DCM）患者（A组）和接受美托洛尔的15例DCM患者（B组）。在治疗1年之前和之后，使用总缺陷评分（TDS）和心脏与纵隔（H / M）活性比来评估心脏（123）I-甲氧苄基胍（（123）I-MIBG）的摄取。延迟的图像。还评估了纽约心脏协会（NYHA）类别和超声心动图检查左心室射血分数（LVEF）。结果：两组的TDS均降低（A组从25 +/- 14降至16 +/- 14，P <0.01; B组从27 +/- 9降至19 +/- 10，P < 0.01），H / M增加（A组从1.67 +/- 0.31增至2.01 +/- 0.36，P <0.01; B组从1.68 +/- 0.21增至1.93 +/- 0.32，P <0.01 ），LVEF增加（A组从31％+/- 10％增至48％+/- 10％，P <0.01; B组从28％+/- 9％增至47％+/- 15 ％，P <0.01）和NYHA功能等级有所改善（A组从2.9 +/- 0.3增至1.7 +/- 0.5，P <0.01; B组从2.8 +/- 0.6增至1.7 +/- 0.6，P <0.01）。 LVEF的变化与A组（r = 0.41）和B组（r = 0.53）的TDS的变化呈轻度相关。在TDS或H / M中反应良好的患者中，NYHA分级比无反应患者的改善更大（P <0.05）。结论：卡维地洛治疗可改善DCM患者的心功能，症状和心脏交感神经活动，其程度与美托洛尔相似。心脏功能和症状的改善与心脏交感神经活动的改善有关。

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