CYP2C8 status of patients with malaria influences selection of Plasmodium falciparum pfmdr1 alleles after amodiaquine-artesunate treatment.

摘要

We have read with great interest the article by Paganotti et al [1], in which evidence is presented about the possible influence of human pharmacoge-netics on the development of chloroquine (CQ) resistance by Plasmodium faldpa-rum. This prompted us to hypothesize that such influence would be more visible and significant when considering the structurally related amodiaquine (AQ). In fact, although CYP2C8 is a secondary player in the metabolism of CQ [2], it is essential for the cytochrome P450 (CYP) associated biotransformation of AQ to its therapeutically main active metabolite, de-sethylamodiaquine (DEAQ) [3].