A methodological and metabolite identification study of the metabolism of S-carboxymethyl-L-cysteine in man

摘要

The analysis of 08:00-16:00 (0-8) hour urine collections following oral S-carboxymethyl-L-cysteine administration of 750 mg to 30 individuals identified S-carboxymethyl-L-cysteine, S-carboxymethyl-L-cysteine S-oxide, S-methyl-L-cysteine and S-methyl-L-cysteine S-oxide as the major urinary drug related compounds. No S-(carboxymethylthio)-L-cysteine mixed disulphide metabolite was found in the 08:00-16:00 hour urine collection but the metabolite was detected in the 16:00-00:00 (8-16) hour urine collection by paper chromatography, TLC and HPLC. The production of the S-oxide metabolites (08:00-16:00 hour urine collection) and the mixed disulphide metabolite (16:00-00:00 hour urine collection) were both shown to be biomodally distributed. A significant linear correlation of the S-oxides recovered following 08:00-16:00 hour urine collection as analysed by paper chromatography, TLC and HPLC is reported. [References: 42]