12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from Streptomyces sp.

摘要

We identified two new radical scavengers, 12T061A (1, C19H20O7) and 12T061C (2, C20H22O7), from a culture of the Streptonzyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED50 of 370 mu M and 18 mu M, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC50: 3.6 mu M); however, no suppressive activity was shown in 2 (IC50: > 100 mu M).