Toxic epidermal necrolysis in a 4-year-old boy successfully treated with plasma exchange in combination with methylprednisolone and i.v. immunoglobulin

摘要

Toxic epidermal necrolysis (TEN) is an acute disease characterized by severe necrosis of the skin that also manifests systemic symptoms.1 It is rare, especially in children, and prompt management is essential for a favorable outcome.1'2 Treatment with corticosteroids and i.v. immunoglobulin (IVIG) are used, however, those sometimes show unsatisfactory efficacy. We present a small pediatric case of anticonvulsant-induced TEN with leukopenia successfully treated with plasma exchange (PE)3 combined with methylprednisolone (mPSL) pulse therapy, IVIG and granulocyte colony-stimulating factor (G-CSF).