Split-face trial of CO 2 laser-induced ring abrasion and high-dose tacalcitol in the treatment of disseminated superficial actinic porokeratosis

摘要

An 83-year-old woman visited our hospital for the treatment of several ring-shaped superficial keratotic papules on her face and forearm, which she had developed 20 years previously (Figs 1a,2a). The patient was clinically diagnosed with disseminated superficial actinic porokeratosis (DSAP) and the diagnosis was confirmed histopathologically. The patient requested treatment for the facial DSAP for cosmetic reasons. Disseminated superficial actinic porokeratosis is characterized by multiple, small disseminated eruptions; the eruptions are typically brown and ring-like and are seen mainly in middle-aged people. Many clinical approaches to treat porokeratosis have been proposed, including CO_2 laser, photodynamic therapy, cryosurgery, Q-switched ruby laser, vitamin D_3 analogs and fractional photo-thermolysis. Most of these treatments, however, do not provide fully satisfactory results and have adverse effects leading to other problems. Although CO_2 laser therapy is mostly effective, severe scarring is an occasional adverse effects of conventional CO_2 laser irradiation.