Human leukocyte antigen G single-nucleotide polymorphism-201 (CC-CC) donor-recipient genotype matching as a predictor of severe cardiac allograft vasculopathy

摘要

BACKGROUND: In heart transplant recipients, human leukocyte antigen G (HLA-G) has been shown to inhibit endothelial and smooth muscle cells injury in vitro, suggesting protection against cardiac allograft vasculopathy (CAV). Although the expression of HLA-G is regulated by single nucleotide polymorphisms (SNPs), their association with CAV remains unknown. Therefore, the objective of this study was to determine the association between recipient and donor HLA-G SNPs with CAV.