Trifluoroacetic Acid-Mediated Nucleophilic Substitution/Smiles Rearrangement Cascade Reaction: An Alternative Approach to Constructing Pyrrole-Fused dihydropteridines

摘要

A trifluoroacetic acid-mediated cascade reaction involving nucleophilic substitution and Smiles rearrangement is described. The reaction of hydroxydihydrodiazepines with primary amines led to amino-substituted dihydrodiazepines, which readily underwent Smiles rearrangement to give pyrrolo[1,2-f]pteridine derivatives.