Dissemination of the New Delhi metallo-beta-lactamase-1 (NDM-1) among Enterobacteriaceae in a tertiary referral hospital in north India.

摘要

Of the different classes of carbapenemases, class B enzymes are clinically the most significant; they possess the widest substrate hydrolysis range, including penicillins, cephalosporins and carbapenems, but not monobactams. In recent years, metallo-p-lactamase (MBL) genes have spread from Pseudomonas aeruginosa to members of the Enterobacteriaceae.1 An alarming report by the HPA UK in 2009 warned of a rapidly proliferating novel carbapenem-hydrolysing p-lactamase (carbapenemase) designated New Delhi MBL-1 (NDM-1) among the Enterobacteriaceae family, identified in UK hospital patients.2 Moreover, the common presence of these p-lactamase genes in transferable mobile elements means that these genes could reach virtually any Gram-negative bacterium and this provides an added risk of dissemination in the community.