Synthesis of enantiomerically enriched 4-aryl-3,4-dihydrocoumarins

摘要

Several synthetic approaches are known for the preparation of chiral 4-aryl-3,4-dihydrocoumarins (DHCs). This article considers recently discovered methods for the synthesis of chiral DHCs: enantio-selective Rh(I)-catalyzed 1,4-addition of arylboronic acids to alpha,beta-unsaturated carbonyl compounds, asymmetric reduction of coumarins, oxidation of chiral indanones, hydroesterification of alkenylphenols, and the addition of 1,3-dicarbonyl compounds to o-quinone methides.