I.Taxonomy,Fermentation,Isolation and Biological Activities Retymicin,Galtamycin B,Saquayamycin Z and Ribofuranosyllumichrome,Novel Secondary Metabolites from Micromonospora sp.Tu 6368

摘要

A new xanthone compound named retymicin (1) was isolated together with galtamycin B (2) and saquayamycin Z (3),new members of the galtamycin and saquayamycin families,respectively,and the new lumichrome derivative l-(alpha-ribofuranosyl)-lumichrome (4) from Micromonospora strain Tu 6368,isolated from a soil sample collected in Romania.Retymicin,galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria.