Synthesis and alkylation of N-Methylmorpholinium 4-Aryl-3-cyano-5-oxo-1,4, 5,6,7,8-hexahydroquinoline-2-selenolates

摘要

A multicomponent reaction of cyanoselenoacetamide with aromatic aldehydes, cyclohexane-1,3-dione, and N-methylmorpholine gave N-methylmorpholinium 4-aryl-3-cyano-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-2-selenolates. Alkylation of the latter occurs under mild conditions with retention of the 1,4-dihydropyridine fragment to give 2-(2-R-methylseleno)-4-aryl-5-oxo-1,4,5,6, 7,8-hexahydro-quinoline-3-carbonitriles.