New xanthoquinodin-like compounds, JBIR-97,-98 and-99, obtained from marine sponge-derived fungus Tritirachium sp. SpB081112MEf2

摘要

Fungi found in marine habitats constitute a rarely used, but promising, resource for discovering novel bioactive substances, such as diketopiperazine alkaloids, trichodermatides and carbonarones. We have recently discovered novel compounds, namely, aspochracin derivative JBIR-15, glycosyl benzenediols JBIR-37 and -38, sorbicil-linoid JBIR-59and JBIR-74 and -75 obtained from marine sponge-derived fungi. To the best of our knowledge, the isolation of fungi from marine sponge Pseudoceratina and their secondary metabolites have been only reported by Boot et al. Therefore, we attempted to isolate fungi from a marine sponge, Pseudoceratina purpurea, to obtain novel substances from the fungal culture. In this study, we isolated new compounds termed JBIR-97 (1), JBIR-98 (2) and JBIR-99 (3) from the culture of Tritirachium sp. SpB081112MEf2 associated with the sponge (Figure la). This paper describes the fermentation, isolation and structure elucidation of 1-3; the biological activity of these compounds is also briefly described.