Trierixin,a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp.II.Structure Elucidation

摘要

Trierixin,a new member of the triene-ansamycin group,has been isolated from the fermentation broth of Streptomyces sp.AC654 as an inhibitor of ER stress-induced XBP1 activation.The structure of trierixin was determined on the basis of its spectroscopical and chemical properties.Trierixin possessed a 21-membered macrocyclic lactam,which contains a methylthio-benzenediol structure,and a cyclohexanecarbonylalanine moiety.Trierixin is thus elucidated as 21-thiomethylmycotrienin II.