N-3-oxoalkylamides and-thioamides in the synthesis of heterocyclic compounde. 7. study of the cyclization of N-(3-oxoalkyl)-amides of tosylacetic acid

摘要

Alkyl-substituted N-(3-oxoalkyl) amides of tosylacetic acid are cyclized under the action of bases with the formation of 3-tosyl-3,6-dihydropyridin-2 (1H)-ones. In the presence of a phenyl substituent at position C_(1) of the 3-oxoalkyl chain the reaction proceeds with the formation of 2-pyridones. The principles influencing the regiodirection of cyclization are explained.