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首页> 外文期刊>The Journal of hand surgery, European volume >Benign eccrine poroma of the dorsum of the hand: predilection for the nail fold and P53 positivity
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Benign eccrine poroma of the dorsum of the hand: predilection for the nail fold and P53 positivity

机译:手背良性内分泌腺瘤:指甲褶皱和P53阳性的好发

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摘要

Dear Sir, Eccrine poromas are benign tumours which arise from the duct epithelium of the intra-epidermal portion of eccrine sweat glands. Eccrine sweat glands are spread throughout the skin although they are known to be absent in certain areas (such as the lid margin, nipple and glans penis) and concentrated in other areas especially the sole of the foot and the palm. This explains the fact that almost all cases of eccrine poromas reported in the hand have been in the palm (Buckley et al., 1993; Mamoun et al., 1972). In this communication we report on a rare case of an eccrine poroma located on the dorsal aspect of the hand. We note that the progression of benign poromas to porocarcinomas may be related to mutations of the P53 oncogene.
机译:尊敬的主席先生,内分泌腺瘤是良性肿瘤,起源于内分泌汗腺表皮内部分的导管上皮。外分泌汗腺分布在整个皮肤,尽管它们在某些区域(例如眼睑边缘,乳头和龟头阴茎)不存在,并且集中在其他区域,尤其是脚掌和手掌。这解释了这样一个事实,即几乎所有报道的手部内分泌性孔瘤病例都在手掌中(Buckley等,1993; Mamoun等,1972)。在本次交流中,我们报告了在手背侧出现罕见的内分泌性孔瘤病例。我们注意到,良性多孔瘤向多孔癌的进展可能与P53癌基因的突变有关。

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