Changes of antibody titers during antimicrobial therapy including levofloxacin for Chlamydia infections in the obstetrics and gynecology field

摘要

During the 6 years from May 1995, Chlamydia antibody titers were measured in nonpregnant and pregnant women. In positive patients, changes of the antibody titer during treatment as well as the transplacental passage of antibodies into cord blood were investigated. 1) Chlamydia antibody-positive patients (n = 45) received the following therapy and changes of the IgA and IgG antibody titers during treatment were investigated: Levofloxacin alone at 300 mg/day for 14 days (n = 29), additional clarithromycin at 400 mg/day for 14 days (n = 10), additional azithromycin at 500 mg/day for 3 days (n = 3), clarithromycin alone at 400 mg/day for 14 days (n = 3). These patients were classified into four groups depending on either they were positive for both IgA and IgG (groups A-C) or were only positive for IgA or IgG (group D). Clearance of antibodies over time tended to be faster for IgA than IgG, but 25/38 (65.8%) showed negative for both antibodies after 6 years. 2) Antibody-positive women who were about 16 weeks pregnant (n = 61) were treated with clarithromycin (400 mg/day for 14 days) and the cord blood antibody titer was measured at the term of delivery. Cord blood IgA was not detected and IgG was strongly correlated with the maternal blood level (r = 0.945).