Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor alpha.

摘要

Diisocyanates are among the most common causes of occupational asthma. However, susceptibility factors and immune bio-markers of diisocyanate asthma (DA) have not been clearly defined. For example, serum diisocyanate antigen-specific IgE and IgG have been extensively investigated, but these immuno-assays lack diagnostic accuracy in identifying workers with confirmed DA. " Various genetic variants have been identified as risk factors for DA in association studies. Certain HLA class II alleles and single nucleotide polymorphisms (SNPs) of antiox-idant enzymes (eg, glutathione-s-transferases, N-acetyl transfer-ases) have been associated with confirmed DA, although these findings have not yet been replicated in multiple populations.