Mammalian meat-induced anaphylaxis: clinical relevance of anti-galactose-alpha-1,3-galactose IgE confirmed by means of skin tests to cetuximab.

摘要

Severe anaphylaxis is often associated with food allergy. Classically, the diagnosis of food allergy is established through a careful evaluation of a patient's allergy history, including skin tests and in vitro tests. If the specific trigger cannot be established, then the patient might be diagnosed with idiopathic anaphylaxis, which is a major concern for both the patient and the physician. Some of these cases are due to rare food allergies.1 Recently, a new specific IgE to galactose-a-l,3-galactose (a-gal) was shown to be linked with anaphylaxis or angioedema reactions to mammalian meats.2'3 The present study reports on 2 cases of anaphylaxis to mammalian meats, which were evaluated by using an in-house a-gal IgE immunoassay4 and novel intra-dermal tests (IDTs) to cetuximab. Cetuximab is an mAb presenting the a-gal oligosaccharide in the Fab portion of the heavy chain.