Dynamic Kinetic Resolution with Enantioselective Borohydride Reduction Catalyzed by Optically Active #beta#-Ketoiminato Cobalt(II) Complexes: Highly Diastereo-and Enantioselective Preparation of Optically Active anti-Aldol Compounds

摘要

Optically active anti-2-alkyl-3-hydroxy esters were stereoselectively obtained from the corresponding 2-alkyl-3-keto esters using enantioselective borohydride reduction along with dynamic kinetic resolution in the presence of optically active #beta#-ketoiminato cobalt complex catalysts. The reduction system provided an alternative preparation for anti-aldol compounds with high diastereo-and enantioselectivities.