Repeated Fc epsilon RI triggering reveals modified mast cell function related to chronic allergic responses in tissue

Suurmond Jolien; Habets Kim L. L.; Tatum Zuotian; Schonkeren Joris J.; t Hoen Peter A. C.; Huizinga Tom W. J.; Laros Jeroen F. J.; Toes Rene E. M.; Kurreeman Fina

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Repeated Fc epsilon RI triggering reveals modified mast cell function related to chronic allergic responses in tissue

机译：重复的Fc epsilon RI触发揭示肥大细胞功能与组织中的慢性过敏反应有关

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Background: Activation of mast cells through Fc epsilon RI plays an important role in acute allergic reactions. However, little is known about the function of mast cells in patients with chronic allergic inflammation or the effect of repeated Fc epsilon RI triggering occurring in such responses.

机译：背景：通过FcεRI激活肥大细胞在急性过敏反应中起重要作用。然而，对于患有慢性变态反应性炎症的患者中肥大细胞的功能或在此类反应中反复发生FcεRI触发的作用知之甚少。

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《The Journal of Allergy and Clinical Immunology 》 |2016年第3期| 共12页
作者
Suurmond Jolien; Habets Kim L. L.; Tatum Zuotian; Schonkeren Joris J.; t Hoen Peter A. C.; Huizinga Tom W. J.; Laros Jeroen F. J.; Toes Rene E. M.; Kurreeman Fina;
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正文语种 eng
中图分类医学免疫学 ;
关键词
Mast cells; IgE; chronic allergy; transcriptome; chronic rhinosinusitis; atopic dermatitis; atopic asthma;

机译：肥大细胞;IgE;慢性过敏;转录组;慢性鼻-鼻窦炎;特应性皮炎;特应性哮喘;

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专利

1. Repeated Fc epsilon RI triggering reveals modified mast cell function related to chronic allergic responses in tissue [J] . Suurmond Jolien, Habets Kim L. L., Tatum Zuotian, The Journal of Allergy and Clinical Immunology . 2016 ,第3期

机译：重复的Fc epsilon RI触发揭示肥大细胞功能与组织中的慢性过敏反应有关
2. Negative regulatory roles of ORMDL3 in the Fc epsilon RI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells [J] . Bugajev Viktor, Halova Ivana, Draberova Lubica, Cellular and molecular life sciences: CMLS . 2016 ,第6期

机译：ORMDL3在FcεRI触发的小鼠肥大细胞促炎性介质表达和趋化反应中的负调控作用
3. Berberine suppresses mast cell-mediated allergic responses via regulating Fc epsilon RI-mediated and MAPK signaling [J] . Fu Shuilian, Ni Saihong, Wang Danni, International immunopharmacology . 2019 ,第期

机译：小檗碱通过调节Fc epsilon Ri介导和MAPK信号传导抑制肥大细胞介导的过敏反应
4. Integrating Control of Mast Cell Function and Allergic Responses [C] . J. Rivera, T. Baumruker, M.A. Beaven, Collegium Internationale Allergologicum . 2007

机译：整合肥大细胞功能和过敏反应的控制
5. FATE OF BONE MARROW-DERIVED CULTURED MAST CELLS AFTER INTRACUT ANEOUS, INTRAPERITONEAL,AND INTRAVENOUS TRANSFER INTO GENETICALLY MAST CELL-DEFICIENT W/Wv MICE Evidence that Cultured Mast Cells Can Give Rise to Both Connective Tissue Type and Mucosal Mast [D] . 仲野, 徹 1988

机译：骨内源性，腹膜内和静脉内转移到遗传上缺乏乳腺的W / Wv小鼠后，骨髓来源的肥大细胞的命运证据表明，培养的肥大细胞可以使结缔组织类型和粘膜肥大同时上升
6. Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses [O] . 1991

机译：通过FcεRI刺激的小鼠肥大细胞释放预先形成的和新合成的肿瘤坏死因子α（TNF-α）/ cachectin。肥大细胞源性TNF-α在IgE依赖性生物应答过程中持续作用的机制
7. Repeated FcεRI triggering reveals modified mast cell function related to chronic allergic responses in tissue [O] . Jolien Suurmond, Kim L.L. Habets, Zuotian Tatum, 2016

机译：重复的FcεRI触发显示与组织中的慢性过敏反应相关的改性肥大细胞功能
8. Opportunities for Studying the Responses of Human Allergic Cells in Tissue Culture. [R] . Pomerat, C. M. 1952

机译：研究人类过敏细胞在组织培养中反应的机会。

Repeated Fc epsilon RI triggering reveals modified mast cell function related to chronic allergic responses in tissue

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