NAT2 slow acetylator associated with anti-tuberculosis drug-induced liver injury in Thai patients

Wattanapokayakit S.; Mushiroda T.; Yanai H.; Wichukchinda N.; Chuchottawon C.; Nedsuwan S.; Rojanawiwat A.; Denjanta S.; Kantima T.; Wongyai J.; Suwankesawong W.; Rungapiromnan W.; Kidkeukarun R.; Bamrungram W.; Chaiwong A.; Suvichapanich S.; Mahasirimongkol S.; Tokunaga K.

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NAT2 slow acetylator associated with anti-tuberculosis drug-induced liver injury in Thai patients

机译：NAT2慢速乙酰化剂与泰国患者抗结核药性肝损伤相关

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BACKGROUND: Anti-tuberculosis drug-induced liver injury (AT-DILI) is one of the most common forms of drug-induced liver injury (DILI) in high tuberculosis (TB) burden countries. Among anti-tuberculosis drugs, isoniazid is the main cause of hepatotoxicity in patients with AT-

机译：背景：抗结核药物性肝损伤（AT-DILI）是高结核病（TB）负担国家中最常见的药物诱导性肝损伤（DILI）形式之一。在抗结核药物中，异烟肼是AT-患者肝毒性的主要原因

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《The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease》 |2016年第10期|共6页
作者
Wattanapokayakit S.; Mushiroda T.; Yanai H.; Wichukchinda N.; Chuchottawon C.; Nedsuwan S.; Rojanawiwat A.; Denjanta S.; Kantima T.; Wongyai J.; Suwankesawong W.; Rungapiromnan W.; Kidkeukarun R.; Bamrungram W.; Chaiwong A.; Suvichapanich S.; Mahasirimongkol S.; Tokunaga K.;
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正文语种 eng
中图分类传染病;
关键词
NAT2; anti-tuberculosis drug-induced liver injury; DILI;

机译：NAT2;抗结核药性肝损伤;DILI;

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1. NAT2 slow acetylator associated with anti-tuberculosis drug-induced liver injury in Thai patients [J] . Wattanapokayakit S., Mushiroda T., Yanai H., The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease . 2016,第10期

机译：NAT2慢速乙酰化剂与泰国患者抗结核药性肝损伤相关
2. NAT2 slow acetylator is associated with anti-tuberculosis drug-induced liver injury severity in indonesian population [J] . Yuliwulandari Rika, Prayuni Kinasih, Susilowati Retno Wilujeng, Pharmacogenomics . 2019,第18期

机译：NAT2慢乙酰乙酰乙酰剂与印度尼西亚人群的抗结核药物诱导的肝损伤严重相关
3. NAT2 ultra-slow acetylator and risk of anti-tuberculosis drug-induced liver injury: a genotype-based meta-analysis [J] . Suvichapanich Supharat, Fukunaga Koya, Zahroh Hilyatuz, Pharmacogenetics and genomics . 2018,第7期

机译：NAT2超慢乙酰剂和抗结核药物诱导肝损伤的风险：基于基因型的Meta分析
4. A Drug-Induced Liver Injury Prediction Model using Transcriptional Response Data with Graph Neural Network [C] . Doyeong Hwang, Minji Jeon, Jaewoo Kang IEEE International Conference on Big Data and Smart Computing . 2020

机译：基于图谱神经网络的转录反应数据的药物诱导的肝损伤预测模型
5. Involvement of Th17 Pathway in Adverse Drug Reactions: Mechanistic Investigation of Drug-Induced Autoimmunity and Drug-induced Liver Injury. [D] . Zhu, Ervin Xu. 2012

机译：Th17途径参与药物不良反应：药物诱发的自身免疫和药物诱发的肝损伤的机制研究。
6. Genomewide Association Study Confirming the Association of NAT2 with Susceptibility to Antituberculosis Drug-Induced Liver Injury in Thai Patients [O] . Supharat Suvichapanich, Sukanya Wattanapokayakit, Taisei Mushiroda, 2019

机译：全基因组关联研究证实了NAT2与泰国患者抗结核药性肝损伤的易感性相关
7. High frequency of NAT2 slow acetylator alleles in the Malay population of Indonesia: an awareness to the anti-tuberculosis drug induced liver injury and cancer [O] . Retno W. Susilowati, Kinasih Prayuni, Intan Razari, 2017

机译：印度尼西亚马来人群NAT2慢乙酰乙酰乙酰乙酰乙酰末等频率：对抗结核药物诱导肝损伤和癌症的认识

NAT2 slow acetylator associated with anti-tuberculosis drug-induced liver injury in Thai patients

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