Nano-silica PAMAM Dendrimer as a Novel Catalyst for Knoevenagel Reactions

摘要

A nano-silica dendrimer, poly(amidoamine)-grafted nano-silica (nano-PAMAM), catalyzed the Knoevenagel reaction of aryl and aliphatic aldehydes with various active methylene coin-pounds at room temperature in good yields. The reaction conditions were mild enough that base-sensitive AcO or acid-sensitive THPO groups remained intact in the products. The catalyst was recycled up to 4 times in 78% average yield.