Effects of chlorhexidine gluconate on cauda epididymis and spermatogenesis of cattle bulls.

摘要

Eight bulls were divided into treated (n=5) and control (n=3) groups. The treated group received 5 ml of 4.5% chlorhexidine gluconate diluted with 50% dimethyl sulfoxide (DMSO) into the cauda epididymis. Control group received 5 ml of 50% DMSO. The bulls in treated group were castrated on days 1, 3, 7, 10, 17, 24, 31, 45, 65 and 90 post-treatment. Control bulls were castrated on days 3, 30 and 90. Transient swelling of the scrotum was observed within 24 hours after injection which persisted up to day 3. No major swelling was observed on subsequent days. Histological changes were chronic in nature, like extensive fibrous tissue proliferation, granuloma formation and sclerosis. Granuloma formation varied from bull to bull. Treatment did not affect spermatogenesis, spermiogenesis and seminiferous epithelial cycle. Chlorhexidine injection into the cauda epididymis proved to be a good chemosterilant to bulls..