Shift to Th2 cytokine response in dengue haemorrhagic fever.

摘要

Fully differentiated CD4~+ helper T (Th)-cells have two major subsets of Thl and Th-2 cells (now Th17 are also appearing on the scene). Th-1 cells are responsible for cell-mediated inflammatory reactions, delayed type hypersensitivity and tissue injury in infections and autoimmune diseases and secrete interferon-gamma (IFN-gamma), interleukin-2 (IL-2) and tumour necrosis factor -beta (TNF-P)). Th-2 cells are associated with help for B cell antibody production and secrete IL-4, IL-5, IL-6, IL-10, and IL-13. Cytokine secretion profiles correlate well with the distinctive functions of these cells. IL-10 and IFN-gamma mediate cross-regulation of the two types of cells in which TNF-alpha is an inducer of IL-10, and IL-10 is a downregulator of TNF-alpha.