Palladium-Catalysed Direct 3-or 4-Arylation of 2,5-Disubstituted Pyrrole Derivatives: An Economically and Environmentally Attractive Procedure

摘要

The arylation of pyrroles is an important field of research in organic synthesis because of their biological or physical properties. Palladium-catalysed Suzuki, Negishi or Stille cross-coupling reactions are among the most important methods to perform the arylation of heteroaromatics.[1] However, these reactions require the preliminary preparation of an organometallic derivative of the pyrrole or of the aryl, which can be tricky, and generate an organometallic salt (MX) as by-product (Scheme 1).